The corona virus SARS-CoV-2 is the etiologic agent of the current pandemic outbreak of COVID-19 that is afflicting humankind through the whole globe since December of 2019. Huge efforts and resources are focused on many aspects of COVID-19 pathology and therapy, and indeed important advancements have been obtained in a relative short period of time. Following modest success with several intuitive and empirical therapeutic approaches (antiviral, antibiotics, anticoagulant, cortisone, immunosuppressive, cytokines) most hopes are currently paying attention to a number immune based therapeutics such as several vaccines already entered in large clinical use. However, though some important insights are also emerging on basic studies addressing SARS-CoV-2 pathogenic mechanisms of action, much have yet to be done in this regard to fully understand SARS-CoV-2 pathogenic processes and therefore implement the most appropriate therapeutic strategies. The extreme complexity of the pathological outcome observed on COVID-19 cannot be successfully solved with palliative therapies by simply using empiric or intuitive approaches. A really rational therapeutic intervention necessarily requires a multidisciplinary strategy with a deep knowledge of all mechanisms involved, and what is more, it might not be even enough to simply know all mechanisms, but also the precise algorithm or time line with which such events take place. It won’t be unexpected to realize that a potentially valuable therapeutic tool given at the wrong time might result into an ineffective outcome or even worse; into deleterious consequences. In this regard it might worth to dedicate widen efforts to better understand the extent by which SARS-CoV-2 might be triggering a cardiovascular misbalance as a primary strategy to escape from an appropriate immune response thus leading to ultimate fatal immune insult.