SAUSSUREA COSTUS AS HERBAL MEDICINES HAVE IMMUNOMODULATORY AND POTENTIAL NUTRACEUTICAL COMPONENTS THAT MAY HELP IN COVID-19 REMEDY
Authors: Marwa M. Elmaghrabi*1 , Najwa M. Majrashi2, Dalal S. Alharbi2 , Najat. A. Marraiki2 , Taha Nazir3, Sead U.R. Nazir4 , Umer Farooq3 , Ishtiaq Rabi3
Keywords: Saussurea costus, COVID-19, Pandemic, Respiratory distress, Medical plants, Herbal medicine.
Abstract
The epidemic associated with the severe acute respiratory syndrome is Corona Viral Disease-2019 (COVID-19) induced thousands of fatalities around the
world. The infection was initially identified in in Wuhan (China) in late December 2019, introduced from zoonotic source. Coronavirus 2 (SARS-CoV-2) is
the extension of severe acute respiratory syndrome and found to have 96% of
its genomic similarity with the bat coronavirus. SARS-CoV-2. That is a singlestranded positive RNA sense virus with a size of 29.7 kb. That also resemble
with the sequence of the Nidovirales, family Coronaviridae, and genus Coronavirus. This kind of RNA encodes two huge non-structural polyproteins and
four main structural proteins. The timely introduction of vaccines and antiviral
therapies have controlled the fatalities of this mortal disease. Moreover, the
Terpenes included in Saussurea can assist in relieving pain and inflammation.
Saussurea costus (S. Costus) has been demonstrated to have antiinflammatory, antiulcer, anticancer, and hepatoprotective effects in vitro and
in vivo experiments. This plant's sesquiterpene lactones, Costunolide, dehydrocostus lactone, and cynaropicrin have all been identified and proven to
have therapeutic promise. So, in this review article we have described the
plant that may help to treat the COVID-19. S. Costus is a crucial plant with
medicinal significance, the roots which are utilized for healing justifications all
over the history of mankind’s giant safety and usefulness. The outputs of other studies showed the existence of several bioactive substances phytochemical molecules that has antiseptic, antibacterial, antifungal, antiviral, antiinflammatory, antioxidant, anti-lipid peroxidation, immunostimulant, analgesic,
bronchodilator, hepatic-protective, and anti-hepatotoxic properties. S. Costus
has immunomodulatory properties on cytokine delivery and has complementinhibitor substances useful in the cure of a few disorders linked to marked
stimulation of the complement system, as in breathing problems.
Article Type:Review article
Received: 2022-06-01
Accepted: 2022-07-25
First Published:7/12/2024 4:22:47 AM
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